Before Saga, Brian K. Vaughan told the tale of Yorick Brown–the only human survivor of a planet-wide plague that instantly kills every mammal with a Y chromosome. In a hostile and destructive world filled with confused and angry women, Yorick, accompanied by his pet monkey Ampersand, searches for his lost love and some form of hope, as things have seriously gone to shit. Equal parts fun, sexy and gut-wrenching, Y: The Last Man was one of the best comics of the 2000s.